Adaptimmune is a leader in TCR T-cell therapy, focused on designing and delivering novel cancer immunotherapy products. We utilize the body’s own machinery – the T-cell – to target and destroy cancer cells. We believe our therapies have the potential to significantly impact cancer treatment and clinical outcomes of people with cancer.

We have developed a proprietary T-cell receptor (TCR) platform that enables us to identify cancer targets, as well as find and genetically engineer TCRs to recognize and attack these targets. We engineer a patient’s own T-cells to express these affinity-enhanced TCRs, to produce TCR T-cell treatments that we call SPEAR (Specific Peptide Enhanced Affinity Receptor) T-cell therapies. We plan on submitting our first Biologics License Application (BLA) by the end of 2022 for afamitresgene autoleucel (“afami-cel”; formerly ADP-A2M4) for the treatment of people with synovial sarcoma.

Our translational science team evaluates our manufactured products, as well as tumor and blood samples from patients collected before and after SPEAR T-cell treatment. This enables us to monitor how our SPEAR T-cells perform and persist in patients, and to examine how the properties of the cells relate to clinical responses. Learnings from our translational research have led to the development of multiple next-generation approaches. Our first next-generation cell therapy targeting MAGE-A4, ADP-A2M4CD8, is currently being evaluated in the SURPASS and SURPASS-2 trials.

We have a deep preclinical pipeline with multiple autologous and allogeneic cell therapy approaches, including new next-generation SPEAR T-cells, more TCR targets, broader HLA coverage, HLA Independent TCRs or HiT therapies eliminating the need for HLA restriction; and next-generation Tumor Infiltrating Lymphocytes (TILs) therapies.

The challenges and opportunities of cell therapy demand specific internal capabilities. Adaptimmune has been built as an integrated cell therapy company, from the ground up, with the sole purpose of designing and delivering cell therapies for people with cancer.